Female individuals with high baseline Aβ had substantially faster tau accumulation relative to male individuals with high baseline Aβ; affected brain areas included inferior temporal and temporal fusiform gyri, as well as the lateral occipital cortex.

The 2025 WHAM Investment Report presents a compelling business case for accelerating investment in women’s health. Produced by Women’s Health Access Matters (WHAM), the report highlights the vast economic and social potential of addressing conditions that exclusively, disproportionately, or differently affect women. Despite representing over half the population and driving 80% of healthcare spending decisions, women’s health remains dramatically underfunded, with only 2% of venture health investments allocated to it. The report outlines key areas of unmet need—such as cardiovascular disease, autoimmune conditions, brain health, and menopause—and showcases success stories from startups and investors capitalizing on this high-growth sector. It calls for data-driven, sex-specific innovation and diverse leadership to unlock transformative returns, improve healthcare outcomes, and close the gender gap in medical research and treatment.

The National Institute on Aging, in conjunction with the Department of Health and Human Services as part of the National Alzheimer’s Project Act, convened a 2020 National Research Summit on Care, Services, and Supports for Persons with Dementia and their Caregivers. This review article addresses research participation by persons living with dementia (PLWD) and their care partners in two different ways: as research participants with input on outcomes studied and as engaged research partners.

This comprehensive characterization provides compelling evidence of sex differences in neuroinflammation emerging during midlife. Notably, the midlife female brain exhibits a profile reminiscent of the inflammatory signature observed in the AD brain. The study presents an opportunity to identify distinct profiles emerging decades before AD diagnosis, and to inform precision medicine interventions that can be implemented to prevent or delay a key driver of AD pathology.

This review describes an overview of sex and gender differences in risk of AD/ADRD and brain structure and function.

This report explores the practical realities physicians face in the absence of sex-specific clinical data and guidelines, documenting their challenges, needs, and perspectives. By analyzing the direct impact on care delivery, identifying where= gaps in knowledge lead to suboptimal outcomes, and highlighting successful integration models, this report proposes actionable pathways to support physicians in providing optimal care for women across medical specialties.

Women are more likely to experience reduced cognitive health later in life. Recent federal efforts seek to address the paucity of research on this phenomenon.